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Specifically, GLP-1RAs reduce SREBP-2 expression via activation of the SIRT6-AMPK pathway, resulting in decreased expression of cholesterol and bile acid synthesis genes, and increased expression of genes associated with RCT and LDL-C uptake

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A.DeleuD.BourkeP

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Citation208,Citation209 Furthermore, cellular senescence is a complex process that cannot be fully addressed by targeting a single aspect, such as cell clearance or SASP modulation

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