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A small clinical trial (N = 82 LOE 1b) in 2013 showed that LC supplementation improved disease indicators and nutritional status in ALS patients with daily supplementation of 1000 mg LC in 40 patients aged 40 to 75 years, while the control group was still given the same amount of placebo [21]

A significant drug main effect ( p = 0.001), as well as a trend-level drug time-point interaction effect ( p = 0.08) was also detected for GLP-1, suggesting that GLP-1 concentrations were lower under cannabis, compared to the placebo condition

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Reductions of glycemic index and hyperinsulinemia by GLP-1 GLP-1 exerts an important effect directly on the brain, and this effect is probably even more important for the analogues than for the endogenous GLP-1 released after ingestion of protein and fat

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