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Caffeine is a methylxanthine that, in addition to increasing lipolytic effects on adipose cells, also suppresses the accumulation of intracellular lipid in adipocytes, inhibits insulin-stimulated glucose uptake and suppresses the differentiation of adipocytes derived from stem cells [25]

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Sonesson, C., Johansson, P

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Detailed phenotyping of patients, which includes not only questionnaires but also other biological measures, is necessary to better understand the links between the biology of ME/CFS and the clinical presentation