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Clinical guidelines generally recommend GLP-1-based therapies for adults with obesity, usually defined as a BMI above 30, or for overweight patients with additional health risks such as type 2 diabetes, high blood pressure, fatty liver disease, sleep apnoea or cardiovascular complications

M1-like macrophages, characterized by elevated glycolysis, disrupted TCA cycle intermediates, enhanced ferritinophagy, and high ROS/NO production, naturally promote ferroptotic pressure

Predictors of incident heart failure in a large insured population: a one million person-year follow- up study