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While previous fiber photometry results showed that administration of GLP-1 or liraglutide did not significantly alter ARC AgRP/NPY neuron calcium signals post 30-minute injection, after 2 hours post-injection, the rapid suppression of AgRP calcium signals after cognition of food was indeed attenuated by liraglutide [49,82,85]

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Treatment-effect on eGFR slopes was assessed by fitting a linear regression model per patient, followed by a t-test to compare the slopes between the groups

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