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Study appraisal and synthesis methods We assessed the quality of studies using the RoB2 tool recommended by the Cochrane Handbook, the NewcastleOttawa Quality Assessment Scale (NOS), the checklist recommended by Agency for Healthcare Research and Quality (AHRQ), and the quality evaluation tool recommended by the National Institutes of Health (NIH)

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Leenheer JA, Rostad CE, Gates PM et al (2001) Molecular resolution and fragmentation of fulvic acid by electrospray ionization/multistage tandem mass spectrometry