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Most studies (Table 4) have shown that LA treatment can improve plasma TG, liver fat accumulation, and weight gain in animals fed an HFD, ultimately producing liver-protective effects

For both of these variables, the combined treatment of semaglutide and cagrilintide were shown to be more effective than either peptide treatment alone

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The peptide itself is only half the equation

Related to this, it has also been described in vitro that GLO2, using SLG as a substrate, can induce the S-glutathionylation of metabolic enzymes of different cellular compartmentalization, in particular malate dehydrogenase, cytochrome b, and complex I from the mitochondria [12,35,50,51], although the relevance of this observations rests to be determined in vivo