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Studies have found that oral administration of puerarin (10 mg/kg and 50 mg/kg) could improve the general symptoms and disease activity of DSS-induced UC, possibly through down-regulating the levels of inflammatory cytokines like TNF-, IL-1 and IL-6, transcription factor NF-B, and other factors such as COX-2, PGE2, NO [250]

51,52 Notably, the molecular mechanisms that regulate self-renewal and differentiation in NSCs are frequently hijacked by CSCs to promote malignant progression

Milanlioglu A, Aslan M, Ozkol H, et al

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