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Biological Activity Dihexa is an orally active, blood-brain barrier-permeable angiotensin IV analog

off-label (for people without the FDA-approved indication)

The standard management approach for these patients involved discontinuation of GLP-1 RAs and supportive care, including intravenous fluids and pain management

Compare your ratings at week 12 to your baseline to quantify improvements

2 Methods 2.1 Eligibility criteria This meta-analysis was registered prospectively in PROSPERO (CRD420251147337) and was carried out following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) recommendations