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So the commonly cited regain curves reflect a very specific scenario: Sudden withdrawal of potent appetite-regulating therapy Removal of dietary, physical activity, and behavioral scaffolding that supported weight loss during the trial phase That combination almost guarantees weight regain and tells us more about biology plus trial design than about real-world inevitability

This incretin effect is considerably attenuated in people with type 2 diabetes (see Figure 1), a loss that is even considered an early indicator of the disease, but it was observed that this deficit could be completely corrected by the continuous infusion of GLP-1 to diabetic patients

I have patients who are in the other situation, where they have been going up on the medication and we have kept them at their current dose and were not escalating during the holidays. Dr

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