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Michael Glickman, MD , is a board-certified family medicine and obesity medicine physician and founder of Revolution Medicine, Health and Fitness

These medications dont produce overnight transformations, but they do begin working in your body almost immediately you just might not see the number on the scale move right away

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This leads to dose-dependent weight loss (typically 8-15% in monotherapy trials), with additive effects when combined with GLP-1 agonists like semaglutide due to complementary mechanisms on energy balance and gastrointestinal function

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