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Clinical trials have shown that the majority of the weight loss typically occurs within the first 16-20 weeks of treatment, with continued gradual weight loss over the following months

Diabetologia 66(10):18691881 Chuang MH, Chen JY, Wang HY, Jiang ZH, Wu VC (2024) Clinical outcomes of Tirzepatide or GLP-1 receptor agonists in individuals with type 2 diabetes

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These include specific kidney conditions such as distal renal tubular acidosis and medullary sponge kidney, gout, hyperparathyroidism, inflammatory bowel disease (particularly Crohn's disease), and recurrent urinary tract infections