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Comment: Many commenters opposed using FDA pathways to determine payment, stating that regulatory status does not correlate with clinical effectiveness, outcomes, or resource use

These could include local irritation, tissue damage, and in rare cases, systemic allergic reactions

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The GLP-1 receptor activation that reduces appetite also slows gastric motility, which causes the sensation of fullness and sometimes nausea

The effectiveness period of these injections varies based on individual factors and metabolism rates, and may last between one to two weeks in the system [12]