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GH/IGF-1 in Muscle and Bone The significance of the GH/IGF-1 axis in the muscular system was highlighted when it was found that calcineurin (CaN), a calcium-calmodulin-dependent protein phosphatase that activates slow isoform of troponin I and myoglobin genes, was regulated by IGF-1 and that inhibiting CaN blocked IGF-mediated hypertrophy of cultured skeletal muscle cells (205)

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Still, a visual inspection of their data shows higher apomorphine exposure for the SC relative to SL formulation over the first 90-min post-dosing, which is consistent with our analysis [27]