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Notably, glucagon, used at 10 nM, increased lipolysis in eWAT explants (Fig

The peptide incorporates two key modifications from native GIP: an aminoisobutyric acid (Aib) substitution at position 2 for DPP-4 resistance and a C-20 eicosanedioic fatty diacid moiety linked at Lys20 via a Glu-2xOEG spacer for albumin binding and half-life extension

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Our study demonstrates that DRP1 hyperactivation induces excessive mitochondrial fission, thereby synergistically enhancing the susceptibility of ATC cells to ferroptosis

( N - tert -butoxycarbonyl)-L-selenocysteine methyl ester was prepared in situ 86 in methanol or phosphate buffer