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Since GLP-1 is cleaved by dipeptidyl peptidase-4 and has a half-life of less than 2 minutes, it is likely that intestinal GLP-1, released after eating, exerts its effect on the brain mainly by interacting with vagus afferent neurons located in the porta hepatis and pylorus

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For a long time, weight and appetite were mostly discussed through the lens of willpower, calories and discipline