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The Pernicious Anaemia Society notes this is well recognised but not fully understood

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This can disrupt communication between the brain and the rest of the body, resulting in symptoms like numbness, weakness, and cognitive issues.In severe cases, B12 deficiency can lead to subacute combined degeneration of the spinal cord, a serious neurological condition that may cause: Stiffness in the limbs Poor coordination Difficulty walking Loss of vibration or position sense If untreated, some of this nerve damage may become permanent

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