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Sharma A, Upadhyay DK, Gupta GD, Narang RK, Rai VK

MPTP The first hint that PD may be related to an environmental toxin came from a report based on a series of patients who developed parkinsonism after exposure to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a contaminant found in synthetic heroin

For patients in Chicago dealing with neuropathic symptoms that have resisted gabapentin, pregabalin, or duloxetine, this mechanism offers a fundamentally different approach: rather than dulling pain signals, ReWire addresses the structural and inflammatory roots of nerve dysfunction

The mechanism story is coherent and supported by multiple studies