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Participants who switched from tirzepatide to placebo regained approximately 14% of their body weight over 52 weeks, while those who continued tirzepatide maintained their weight loss and even achieved modest additional reductions

Potential Benefits & Considerations Observations from preclinical and clinical literature on the component peptides

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The suspected mechanism is glucagon activity: the glucagon receptor is expressed in certain tissues of the peripheral nervous system, and its chronic activation appears to alter neurosensory signaling in some subjects

The location of the ischemia in the descending and sigmoid of our case follows the segmental nature of colonic ischemia