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Neurological examination revealed mild weakness in the bilateral upper and proximal lower limbs, brisk deep tendon reflexes and bilateral extensor plantar response, suggesting myelopathy

They simply cannot reach the brain in therapeutic concentrations

Metabolomics captures complex aspects of human biology, reflective of individual genomics and environmental exposures and, together with direct pharmacogenomic approaches, brings closer the prospect of precision medicine [84,85]

Korea Drug Development Fund funded by Ministry of Science and ICT, Ministry of Trade, Industry, and Energy, and Ministry of Health and Welfare (HN21C1076)

It sits between cosmetic-grade (formulated for topical use, often 1% in a serum base with no parenteral endotoxin spec) and pharmaceutical-grade (a licensed medicinal product manufactured under full UK GMP per the Human Medicines Regulations 2012)