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Ultimately, 69 participants completed the study, consisting of 34 individuals in the NAC (case) group and 35 in the placebo (control) group, who were included in the final analysis (Figure 1)

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The saliva proteome holds an excellent promise for HA research as it is a noninvasive body fluid and can be effectively used in devising effective strategies for the screening of HA fitness and early diagnosis of HA-induced pathologies