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Silymarin acts as an antioxidant by reducing the production of free radicals

Although uptake was initially modest due to cost, insurance coverage, and administration requirements, use has been expanding as both patients and providers seek alternatives to injections

Its relevance to neuropathy is most direct in the metabolic neuropathies, particularly diabetic peripheral neuropathy, where impaired glucose metabolism, insulin resistance, and mitochondrial dysfunction all contribute to nerve damage

Doses stay comfortable and are closely monitored

Induction of oxidative stress by restraint stress and corticosterone treatments in rats