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ROS exacerbate the severity of asthma symptoms by activating inflammatory mediators that cause airway smooth muscle contraction, promote mucus hypersecretion, increase the permeability of lung capillaries, and damage cell membranes

Originally based on three syntypes, of which two are still held in the National Museum of Natural History, Smithsonian Institution, Washington, DC, both collected at Petropavlovsk-Kamchatski, Kamchatka District, Far Eastern Russia, by Leonhard Hess Stejneger (18511943), an adult male collected on 29 June 1882 (USNM 89144) and a second adult male collected on 30 September 1883 (USNM 92695) (31)

Compounded medications are rarely covered by insurance but cost less than most insurance copays and can be purchased with HSA/FSA funds

doi: 10.1186/1743-7075-10-28

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