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Research in animal models suggests that Epitalon may influence pineal gland function and support melatonin secretion

In the context of Drosophila , O-GlcNAcylation has been identified as a critical PTM that governs circadian regulation and influences the pace of the internal clock [99]

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Although other environmental factors, such as radiation, xenobiotics, air and water pollutants are also important pro-oxidant components, there were no study included these factors in OBS due to data limitation

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