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The fourth option is exemplified by the use of the streptococcal endopeptidase imflimidase, which cleaves the HC of all four subclasses of IgG and the IgG-like B cell receptor on CD19 + memory B cells [410,411,412], thereby depleting the IgG pool and possibly lowering the production of IgG [410, 413]

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If you dont get enough vitamin B12, you might feel lethargic, fatigued, and worn out all the time