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Clinical implication Considering the potential for gastric food retention and aspiration risks associated with surgical or endoscopic interventions, the American Society of Anesthesiologists recommends the discontinuation of short-acting GLP-1 RAs one day and long-acting formulations at least 1 week before surgical procedures [27]

Concomitant ICV administration of GLP- 1 and GIP significantly reduced food intake, body weight, and alcohol consumption

Only 27.7% and 7.8% of the enrolled patients were women or aged 75 years or older, respectively [81]

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Long-term effectiveness and safety of metreleptin in the treatment of patients with generalized lipodystrophy