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It also promotes the increase of lighter melanin over darker melanin, leading to even-toned, brighter, and more radiant skin from head to toe

10.1186/s13073-021-00851-9 Genome Med

Its ability to stabilize the plaque depends on its thickness and collagen content

PUMA mediates cell apoptosis in response to the tumor necrosis factor (TNF)-related apoptosis-inducing ligand and ferroptosis inducers, and p53 may regulate ferroptosis and apoptosis as a key factor in the crosstalk of the two death mechanisms through PUMA regulation (74)

En la consulta realizamos una valoracin integral para indicar el tratamiento ms adecuado a cada paciente