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EPM, elevated-plus-maze
The rd1 mouse is a common animal model used to study RP in which the expression of over 60 genes, related to proliferation, apoptosis, and transcription, is modified via a mutation in the phosphodiesterase-6 gene, which affects the metabolism of cyclic guanosine monophosphate
Tant que le glutathion reste sous cette forme rduite, il peut assurer pleinement ses fonctions de dfense
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