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Side effects are most pronounced during dose escalation and tend to improve at each dose level as the body adapts before the next increase

If you develop a side effect while taking this drug and want to tell the FDA about it, visit MedWatch or call 800-FDA-1088

There is also a 5-year Phase III clinical trial (NCT04822181) underway to investigate the efficacy and safety of semaglutide monotherapy in patients with NASH without cirrhosis, assessing the primary endpoints of progression of cirrhosis, regression of steatohepatitis, inflammation, and histological changes in balloon-like hepatocytes

However, theres a huge debate for knowing why injectables are invented and prescribed if the oral formulation is available

doi: 10.1038/s41591-025-03774-9 182 GruberTLechnerFKriegerJPGarca-CceresC