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Adding further complexity, regional heterogeneity in microglial phenotypes, such as differences between striatal and cortical microglia in PD, can influence treatment responses and must be carefully considered in the design of targeted therapies

In the NAFLD animal model, hepatic GLP-1R expression levels at the NAFL (8 weeks) and NASH (16 weeks) stages were downregulated, consistent with the data in humans

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