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This actin-regulatory activity underlies TB-500's profound effects on cellular migration, with research showing the peptide increases cell migration rates 2-3 fold through enhanced formation of dynamic membrane protrusions and improved directional persistence

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Its structure consists of a disulfide bridge between cysteine residues 3 and 15, which is crucial for its biological activity

These changes result in functional impairments due to changes in hemodynamic forces, the structural integrity of the vascular walls, and other contributing factors [93]