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Women undergoing hormone replacement therapy may therefore experience amplified responses to MOTS-c, a clinically relevant interaction that warrants monitoring

The repair signature is reminiscent of the copper signature very recently demonstrated in regulatory T cells, whose energetic and functional phenotype is highly dependent on free intracellular copper

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The strategy of interrogating a single growth-hormone-axis pathway through a defined molecule parallels the contemporaneous lineage of growth-hormone secretagogues such as CJC-1295 with DAC, which pursued the complementary aim of prolonging endogenous GH release rather than isolating a fragment