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Mood changes are not listed as common side effects in tirzepatide prescribing information, and the FDA has not found clear evidence linking GLP-1 receptor agonists to depression or suicidal thoughts

GLP-1 drugs may be underprescribed for men, who are much more likely to die prematurely from heart disease

Peer review Peer review information Nature Chemical Biology thanks Rudi Fasan and the other, anonymous reviewer(s) for their contribution to the peer review of this work

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