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Mitochondrial GSH sequesters copper, preventing its binding to lipoylated proteins, such as DLAT, thereby blocking the aberrant protein oligomerization that drives this cell death pathway [109]

These peptides are not appropriate for self-directed experimentation

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Impairment of lipophagy by PNPLA1 mutations causes lipid droplet accumulation in primary fibroblasts of Autosomal Recessive Congenital Ichthyosis patients

Then we designed shRNA targeting the ATG10 gene, an E2-like enzyme involved in autophagy that catalyzes the conjugation of ATG12 to ATG5 ( ATG10 expression level revealed that the affinity cell sorting led to a significantly increased shRNA knockdown efficiency of 60% in the sorted cells, compared to a knockdown efficiency of 7% in the before sorting cells (Figure 5B)