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Two reports in cerebrospinal fluid analysis found equivalence between ME/CFS and control except for reduced mannose and acetylcarnitine in ME/CFS 19 and a hypometabolic profile with decreases in tryptophan, glutamate, butyrate, polyamine and tricarboxylic acid (TCA) cycle pathways in ME/CFS 20

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Typical Dose: 6001,200 mg 12 daily

One example escalation schedule observed in Phase 2 obesity trials proceeded broadly as follows: Weeks 14: 2 mg once weekly (initiation phase) Weeks 58: 4 mg once weekly Weeks 912: 8 mg once weekly Weeks 13 onwards: Up to 12 mg once weekly (the maximum dose explored in Phase 2 trials) This is an illustrative example only

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