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In laboratory studies, 5-Amino-1MQ has been evaluated for its interaction with nicotinamide N-methyltransferase (NNMT)-associated enzymatic pathways and downstream NAD+-related and methylation signaling under controlled experimental conditions

10.1172/JCI90328 J

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But animal studies extending up to 6 months show no organ toxicity or adverse histological changes (Sikiric et al., Toxicology and Applied Pharmacology, 2019)