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[DOI] [PMC free article] [PubMed] [Google Scholar] 27.Rekatsina M., Paladini A., Piroli A., Zis P., Pergolizzi J.V., Varrassi G

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It is released from the extracellular matrix during tissue injury specifically cleaved from SPARC (Secreted Protein Acidic and Rich in Cysteine) and the alpha 2(I) chain of type I collagen.[2] Age-related decline: Plasma concentration declines from approximately 200 ng/mL (10 M) at age 20 to roughly 80 ng/mL by age 60