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Obesity causes decreased tidal volumes due to a reduction in chest expansion that is caused both by the weight on the chest itself and the effect of abdominal obesity on flattening the diaphragm

The broader impact includes erosion of trust in telemedicine

This mechanism has also been proposed for glucose/fructose-mediated GLP-1 secretion in-vitro and in the perfused rat small intestine [20, 31]

3,5 Although these lipidated GLP-1 analogues have been widely characterized in terms of their pharmacokinetic properties, there have been only a few studies characterizing their biophysical properties and physical stability

The company also stressed that "obesity is about more than just a number on a scale" and that Wegovy is the only one of its class of drugs that's been shown to reduce risk of major cardiovascular events