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The following timeframes are supported by clinical trial data and prescribing information: Nausea: Most commonly peaks in the first one to two weeks at each dose level, then improves significantly over weeks three to four

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This is particularly important during dose escalation periods when side effects tend to spike

Patients with seizure disorders, active eating disorders, uncontrolled hypertension, or a personal/family history of bipolar disorder should avoid bupropion