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In a randomized, placebo-controlled intervention study with more than 900 older participants experiencing psychological distress, daily supplementation with folic acid (400 g) and vitamin B 12 (100 g) for two years did not reduce the occurrence of symptoms of depression despite significantly improving blood folate, vitamin B 12 , and homocysteine levels compared to placebo (109)

People with GI disorders like Crohns syndrome and celiac disease are often unable to break down and absorb dietary B12 and oral B12 supplements, leaving them deficient

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Your choice depends on your research protocol and how precise your measurements need to be