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How GLP-1 Medications Work With these particular weight loss/T2D medications, active ingredients Semaglutide and tirzepatide mimic GLP-1 (Glucagon-like peptide-1), the naturally occurring hormone produced in the GI tract

G.HuangL.et al (2024)

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Cholelithiasis (gallstones) like GLP-1, due to rapid weight loss