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1 To appreciate what an unusual achievement this is, it helps to remember why non-peptide agonists of GLP-1 were considered so hard: the receptor is a class B G-protein-coupled receptor whose natural ligand is a 30-residue peptide that drapes across a large, shallow binding surface

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Combined with the systemic anti-aging effects on gene expression, this peptide delivers value beyond just skin appearance

It means that many of the dramatic effects reported in cell studies have not translated reliably to human outcomes