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In the first pathway, DA is deaminated by monoamine oxidase (MAO) to form 3,4-dihydroxyphenylacetaldehyde (DOPAL), which is then oxidized by aldehyde dehydrogenase (ALDH) to form 3,4-dihydroxyphenylacetic acid (DOPAC)

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I think that's just the way it works out

Additionally, 44.1% in the naltrexone/bupropion group and 26.3% in the placebo group achieved an HbA1c of less than 7%, a significant difference