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Similar content being viewed by others Introduction As the largest endocrine gland in the human body, the thyroid plays a crucial role in regulating growth and metabolism by synthesizing thyroid hormones (Zhang et al

Further mechanistic studies revealed that LPS downregulates UFL1 expression, activates p53/SLC7A11 system, and modulates autophagy, thereby inducing ferroptosis ( 4.2.3 Bile acids Bile acids (BAs) metabolism disorders constitute a significant component of metabolic abnormalities in PCOS ( Notably, BAs -mediated activation of FXR has been reported to suppress lipid peroxidation and inhibit ferroptosis

By addressing IBS and SIBO through this interconnected approach, the goal is not simply symptom relief, but restoration of balance and long-term gut health

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