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[39] What this means is that, disruptions that occur to the gut (for instance, from taking an antibiotic, taking acid-suppressing medications for acid reflux , or eating an inflammatory food like gluten ), can upset the microbiome, cause intestinal permeability ( leaky gut ), and result in a shared gut-brain inflammatory event

These primary data suggest that carriers of the Thr92Ala polymorphism may experience inadequate intracerebral T3 availability despite standard replacement therapy, contributing to persistent symptoms