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Hinwood AL, Callan AC, Ramalingam M, et al

RNR-dependent nucleotide synthesis may therefore compete with GPX4-dependent lipid hydroperoxide reduction for use of the same co-substrate, namely GSH

However, its application is limited by poor water solubility and high preclinical effective dosage

A phase 3, randomized, controlled trial of resmetirom in NASH with liver fibrosis

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