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These data are limited and uncontrolled, so they should guide, not guarantee, expectations

That means the ability to be nimble when designing the benefit, transparent communication channels, and the right partner built on the right model with the right alignment is the key to success

These mechanisms operate independently of weight loss, meaning cardiac benefits begin before significant pounds drop

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Thus, this evidence supports the conclusion that, in addition to rigorous lifestyle interventions, pharmacological gains must be evaluated via stratification based on specific populations and target endpoints