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Description

Subcellular Hsp70 inhibitors promote cancer cell death via different mechanisms

Cytokines such as IL-6 and interferon can activate JAK2/STAT3 signaling pathway and phosphorylate STAT3

Apr 2020;25(4):310-318

By utilizing patient-specific organoid models combined with real-time drug response monitoring, researchers can accelerate the discovery of clinically relevant CSC vulnerabilities and optimize treatment strategies before clinical translation