In summary, cinnamon phytonutrients engage TRP channels as key mediators (e.g., cinnamaldehyde on TRPA1 (primary) and, to some extent, TRPV1) via eugenol or cross-activation
doi: 10.1093/schbul/sbab066
The Triple Agonist Mechanism and Weight Loss Huberman described retatrutide as a triple agonist of the GLP-1, glucagon, and GIP receptors, and noted that it is sometimes referred to as "GLP-3." He made a striking claim about the weight loss data: "In a phase three clinical trial in humans, it caused up to one-third loss of body weight
Why Continuous GLP-1 Treatment Prevents Weight Cycling Discontinuing and restarting GLP-1 medicationssometimes called 'yo-yo' or weight cyclingcreates metabolic stress that may worsen insulin sensitivity and increase future weight-regain risk
This article provides evidence-based guidance on using Wegovy and antibiotics together, addressing common concerns and highlighting when to seek clinical advice