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Although many types of hepatoprotective drugs are available, GSH is often overused by clinicians, with its effects on tumors being overlooked

Thyroid medications deserve particular attention

These mechanisms influence cellular processes such as cell proliferation, differentiation, and metabolism, among others ( Intracellular receptors involved in the neuroactive steroids signal transduction are progesterone (PR, isoforms: PR-A, and PR-B), glucocorticoid (GR, with several splice variant isoforms, such as GR-), androgen (AR, with different splice variant), estrogen (ER, subtypes coded in different genes: ER, and ER), and mineralocorticoid receptor (MR, with several splice variant isoforms, including MR and MR)

This opens the prospect of integrative approaches combining pharmacotherapy with microbiome modulation and establishes a foundation for novel strategies, such as genetically engineered probiotics capable of locally producing GLP-1 in the intestine

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